期刊
FUTURE MEDICINAL CHEMISTRY
卷 7, 期 16, 页码 2195-2219出版社
FUTURE SCI LTD
DOI: 10.4155/fmc.15.138
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资金
- Deutsche Forschungsgemeinschaft (DFG) [OT 414/2-1, SFB 1093]
- European Commission (IAPP) [286418]
Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach. Here, we summarize the current state of small-molecule inhibition and stabilization of PPIs and review the active molecules from a structural and medicinal chemistry angle, especially focusing on the key examples of iNOS, LFA-1 and 14-3-3.
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