相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond
Bart De Strooper et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)
Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators
Maximillian A. Rogers et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage
Yohei Shibuya et al.
NEUROBIOLOGY OF AGING (2015)
Amyloid-β Efflux from the Central Nervous System into the Plasma
Kaleigh Filisa Roberts et al.
ANNALS OF NEUROLOGY (2014)
Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1-42 Clearance
Yohei Shibuya et al.
JOURNAL OF NEUROSCIENCE (2014)
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Stephen Salloway et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Rachelle S. Doody et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis
Li-Hao Huang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
Jing Zhou et al.
CELL RESEARCH (2013)
Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
Yasuomi Urano et al.
FASEB JOURNAL (2013)
Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts
Raja Bhattacharyya et al.
JOURNAL OF NEUROSCIENCE (2013)
Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease
Stephanie R. Murphy et al.
MOLECULAR THERAPY (2013)
Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease
Yoko Tajima et al.
LIPIDS IN HEALTH AND DISEASE (2013)
Autophagosomes form at ER-mitochondria contact sites
Maho Hamasaki et al.
NATURE (2013)
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease
Kurt M. Lucin et al.
NEURON (2013)
Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Ana Griciuc et al.
NEURON (2013)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
Estela Area-Gomez et al.
EMBO JOURNAL (2012)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre et al.
EMBO JOURNAL (2012)
Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
Robin B. Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Cellular Pregnenolone Esterification by Acyl-CoA:Cholesterol Acyltransferase
Maximillian A. Rogers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
Ulrike Krueger et al.
NEUROBIOLOGY OF AGING (2012)
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Paige E. Cramer et al.
SCIENCE (2012)
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson et al.
SCIENCE SIGNALING (2012)
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
Eva-Maria Mandelkow et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Biochemistry of Amyloid β-Protein and Amyloid Deposits in Alzheimer Disease
Colin L. Masters et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Dynamic Analysis of Amyloid β-Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal Aβ during Age-Related Plaque Formation
Soyon Hong et al.
JOURNAL OF NEUROSCIENCE (2011)
Linking lipids to Alzheimer's disease: cholesterol and beyond
Gilbert Di Paolo et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Mechanism mediating oligomeric Aβ clearance by naive primary microglia
Cheng-Ning Yang et al.
NEUROBIOLOGY OF DISEASE (2011)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
Smita Majumder et al.
PLOS ONE (2011)
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
Ming Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Joseph M. Castellano et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
The acetylation of tau inhibits its function and promotes pathological tau aggregation
Todd J. Cohen et al.
NATURE COMMUNICATIONS (2011)
Purification of Recombinant Acyl-Coenzyme A:Cholesterol Acyltransferase 1 (ACAT1) from H293 Cells and Binding Studies between the Enzyme and Substrates Using Difference Intrinsic Fluorescence Spectroscopy
Catherine C. Y. Chang et al.
BIOCHEMISTRY (2010)
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Lars M. Ittner et al.
CELL (2010)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice
James J. Donkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice
Henri J. Huttunen et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Detergent-Resistant Microdomains Determine the Localization of σ-1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction
Teruo Hayashi et al.
MOLECULAR PHARMACOLOGY (2010)
Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease
Eloise Hudry et al.
MOLECULAR THERAPY (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
The secretases: enzymes with therapeutic potential in Alzheimer disease
Bart De Strooper et al.
NATURE REVIEWS NEUROLOGY (2010)
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min et al.
NEURON (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
Elena Y. Bryleva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Acyl-coenzyme A: cholesterol acyltransferases
Ta-Yuan Chang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain
David W. Russell et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Fusion Step-Specific Influence of Cholesterol on SNARE-Mediated Membrane Fusion
Jinyoung Chang et al.
BIOPHYSICAL JOURNAL (2009)
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway
Henri J. Huttunen et al.
FASEB JOURNAL (2009)
Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function
John A. Schmidt et al.
JOURNAL OF CELL BIOLOGY (2009)
Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Kelly R. Bales et al.
JOURNAL OF NEUROSCIENCE (2009)
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
Paul Saftig et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients With Alzheimer Disease
Felicia C. Goldstein et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2008)
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
Jing Yang et al.
CELL (2008)
Direct and potent regulation of γ-secretase by its lipid microenvironment
Pamela Osenkowski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
Rashid Deane et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
Suzanne E. Hickman et al.
JOURNAL OF NEUROSCIENCE (2008)
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
Melanie Meyer-Luehmann et al.
NATURE (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
ApoE promotes the proteolytic degradation of Aβ
Qingguang Jiang et al.
NEURON (2008)
Alzheimer's disease: the lipid connection
Tobias Hartmann et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
Erik D. Roberson et al.
SCIENCE (2007)
Knockdown of ACAT-1 reduces amyloidogenic processing of APP
Henri J. Huttunen et al.
FEBS LETTERS (2007)
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels
Mami Ikenoya et al.
ATHEROSCLEROSIS (2007)
The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
David R. Riddell et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
Sovan Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Carlo Ballatore et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Autophagy is activated for cell survival after endoplasmic reticulum stress
Maiko Ogata et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Control of peripheral nerve myelination by the β-secretase BACE1
Michael Willem et al.
SCIENCE (2006)
A specific amyloid-β protein assembly in the brain impairs memory
S Lesné et al.
NATURE (2006)
From acute ER stress to physiological roles of the Unfolded Protein Response
J Wu et al.
CELL DEATH AND DIFFERENTIATION (2006)
Protein sensors for membrane sterols
JL Goldstein et al.
CELL (2006)
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird et al.
JOURNAL OF NEUROSCIENCE (2005)
Lipids as modulators of proteolytic activity of BACE - Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
L Kalvodova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion
MA Churchward et al.
JOURNAL OF CELL SCIENCE (2005)
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
SE Wahrle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
S Oddo et al.
NEURON (2004)
Cholesterol metabolism in the central nervous system during early development and in the mature animal
JM Dietschy et al.
JOURNAL OF LIPID RESEARCH (2004)
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
M Koistinaho et al.
NATURE MEDICINE (2004)
Effects of the acyl coenzyme A:: Cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
JC Tardif et al.
CIRCULATION (2004)
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
B Hutter-Paier et al.
NEURON (2004)
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
B Feng et al.
NATURE CELL BIOLOGY (2003)
Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction
S Oddo et al.
NEURON (2003)
Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
MA Pappolla et al.
NEUROLOGY (2003)
Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease
C Hock et al.
NEURON (2003)
Cholesterol is superior to 7-ketocholesterol or 7α-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1
Y Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
EL Willner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Acyl-coenzyme A : cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: In vivo and in vitro studies
N Sakashita et al.
LABORATORY INVESTIGATION (2003)
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism
AJ Brown et al.
MOLECULAR CELL (2002)
Tau is essential to β-amyloid-induced neurotoxicity
M Rapoport et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
S Wahrle et al.
NEUROBIOLOGY OF DISEASE (2002)
Influence of membrane partitioning on inhibitors of membrane-bound enzymes
R Homan et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
K Fassbender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A role for ghrelin in the central regulation of feeding
M Nakazato et al.
NATURE (2001)
Tau filament formation in transgenic mice expressing P301L tau
J Götz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2000)
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
J Lewis et al.
NATURE GENETICS (2000)
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
H Yagyu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
DM Holtzman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
M Accad et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling
K Hofmann
TRENDS IN BIOCHEMICAL SCIENCES (2000)
Conformational change as one of the earliest alterations of tan in Alzheimer's disease
CL Weaver et al.
NEUROBIOLOGY OF AGING (2000)
分享论文
