期刊
LEARNING & MEMORY
卷 22, 期 4, 页码 197-202出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.036590.114
关键词
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资金
- Systems and Integrative Biology Training grant [GM07517]
- NIH training grant [HL07953]
- National Institutes of Health [P50 AG 017628, RO1 MH 099544]
Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.
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