期刊
FOOD CHEMISTRY
卷 258, 期 -, 页码 35-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.03.052
关键词
Neutral and acidic monosaccharides; Metal elements; Molecular weight; Reaction groups; Mouse bio-indices interplay
资金
- National Science & Technology Pillar Program in the 12th Five-year Plan of China [2012BAD36BO7-04]
- Shandong Double Tops Program [SYT2017XTTD04]
Chinese jujube is commonly used in folklore medicine. This study aimed to examine the in vivo immunomodulatory activity of two acidic polysaccharides, HP1 and HP2, extracted and purified from Zizyphus jujuba cv. Huizao (which remains extensively unexplored). HP1 and HP2 had the same monosaccharide species and manganese contents, but differed in their molar rhamnose, arabinose, mannose, glucose, galactose and uronic acid contents (7.32 and 35.9%, as galacturonic acid), Mw (68.7 and 111 kDa, respectively), and contents of K, Cr, Cu, Zn, Pb and Ca. Both HP1 and HP2 could significantly (P < 0.05) increase spleen and thymus indices, promote serum hemolysin formation, enhance the phagocytic activity of macrophages and inhibit footpad edema of mice, with HP2 likely being a more consistent and potent immunomodulator. This study clearly demonstrates the potential of Z. jujuba cv. Huizao polysaccharides as immunomodulators and their associated chemical characteristics and working mechanisms.
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