期刊
FOOD CHEMISTRY
卷 266, 期 -, 页码 359-367出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.06.032
关键词
Apoptosis; AIF; Factors; Bovine longissimus muscle; Postmortem aging
资金
- National Natural Science Foundation of China [31560463, 31771905]
- Fostering Foundation for the Excellent Ph.D. Dissertation of Gansu Agricultural University [2017003]
- China Agriculture Research System [CARS-38]
This study investigated the apoptosis pathway mediated by apoptosis-inducing factors (AIF) and internal factors that influence the release of AIF. The results indicated that the AIF expression was decreased in mitochondria and increased in nucleus (P < 0.05). However, no significant differences were observed in the AIF expression in mitochondria with caspase inhibitor treatment. The optical density of nucleus and mitochondrial swelling was significant increased (P < 0.05). Reactive oxygen species (ROS) fell gradually within the first 6 h and increased in the next 24 h. Calpain I activity was decreased, Ca2+ concentration, cathepsin B and D activities was increased (P < 0.05). The results demonstrated that AIF-mediated caspase-dependent pathway was a new mitochondrial apoptosis pathway and that mitochondrial swelling, ROS content, Ca2+ concentration, calpain I, cathepsin B and cathepsin D activities are the key influencing factors in apoptosis in postmortem bovine muscle.
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