期刊
FOOD CHEMISTRY
卷 249, 期 -, 页码 193-201出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.01.017
关键词
Conjugated linoleic acid; CLA; Caenorhabditis elegans
资金
- National Institute of Food and Agriculture, U.S. Department of Agriculture
- Massachusetts Agricultural Experiment Station
- Department of Food Science, the University of Massachusetts Amherst [MAS00450, MAS 00492]
- USDA National Needs Fellowship
- Indiana Clinical and Translational Sciences Institute [UL1TR001108]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- China Scholarship Council
Conjugated linoleic acid (CLA) has been reported to reduce fat storage in cell culture and animal models. In the current study, the effects of CLA on the fat accumulation, activities, and proteomics were investigated using Caenorhabditis elegans. 100 mu M CLA-TG nanoemulsion significantly reduced fat accumulation by 29% compared to linoleic acid (LA)-TG treatment via sir-2.1 (the ortholog of Sirtuin 1), without altering the worm size, growth rate, and pumping rate of C. elegans. CLA significantly increased moving speed and amplitude (the average centroid displacement over the entire track) of wild type worms compared to the LA group and these effects were dependent on aak-2 (AMPKa ortholog) and sir-2.1. Proteomics analysis showed CLA treatment influences various proteins associated in reproduction and development, translation, metabolic processes, and catabolism and proteolysis, in C. elegans. We have also confirmed the proteomics data that CLA reduced the fat accumulation via abs-1 (ATP Synthase B homolog). However, there were no significant effects of CLA on brood size, progeny numbers, and hatchability compared to LA treatment.
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