4.7 Article

Identification of new diterpene esters from green Arabica coffee beans, and their platelet aggregation accelerating activities

期刊

FOOD CHEMISTRY
卷 263, 期 -, 页码 251-257

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ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.04.081

关键词

Coffea arabica; Coffee lipids; Diterpene esters; Structure elucidation; Platelet aggregation

资金

  1. National Natural Science Foundation of China [31670364]
  2. Project of Key New Productions of Yunnan Province, Centre of CHINA [2015BB002, 2016HE003]

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Eight new ent-kaurane diterpene fatty acid esters, namely caffarolides A-H (1-8), were isolated from green beans of Coffea arabica. Their chemical structures were confirmed by extensive spectroscopic analysis including 1D, 2D NMR (HSQC, HMBC, H-1-H-1 COSY, and ROESY), HRMS, IR and CD spectra and by GC-FID analysis. Interestingly, the diterpene moiety of these new compounds first occurred in genus Coffea. All the isolates were evaluated for platelet aggregation activity in vitro. As the results, caffarolides C, D and F (3, 4 and 6) showed induction effect for platelet aggregation and the possible structure-activity relationships have been discussed briefly.

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