期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 115, 期 -, 页码 20-25出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2018.02.060
关键词
Bisphenol A; 5 alpha-reductase isozymes; Aromatase; Prostate
资金
- Spanish Ministry of Science and Innovation [BFU 2008-05340]
- Andalusian Regional Government [Endocrinology & Metabolism Group] [CTS-202]
The impact of bisphenol A (BPA) on the prostate gland has taken center stage, with a special focus placed on understanding how BPA affects prostate physiopathology. In this study, we evaluated the ability of lower doses of BPA to induce alterations in 5 alpha-R isozymes and aromatase, in the prostate of juvenile rats exposed during developmental stage. Gestating Wistar rats were treated s.c with either vehicle or BPA (2.4 and 10 mu g/kg b.w./day) from gestational day 12 to parturition. Then, male pups were s.c treated from postnatal day 1 through day 21, when they were euthanized and qRT-PCR, western blot and hormone levels determination were performed. We found that BPA at dose of 2.4 and 10 mu g/kg b.w./day significantly decreased the mRNA and protein levels of 5 alpha-R2. However, neither 5 alpha-R1 nor 5 alpha-R3 was affected by this exposure. BPA at dose of 10 mu g/kg b.w./day significantly increased the mRNA and protein levels of aromatase. BPA also decreased plasma levels of both testosterone and dihydrotestosterone and increased estradiol. These data lend support that low-dose SPA during fetal and neonatal prostate development interfere with in situ estrogen and androgen production in the prostate gland of juvenile rats through the enzymes aromatase and 5 alpha-Reductase.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据