期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 119, 期 -, 页码 176-188出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2018.04.052
关键词
Natural flavonoids; Structure activity relationship studies; Monoamine oxidase; BDNF; Serotonergic system; Dopaminergic system
资金
- Spanish Instituto the Salud Carlos III [CIBEROBN - CB12/03/30038]
Depression, a multifactorial brain disorder, is one of the most prevalent diseases worldwide. Several strategies have been developed to counteract the main symptoms and disorders. However, the treatments are usually associated with different side effects or poor effect. For that reason, new necessary approaches are emerging; among them, natural products are good alternatives since no interactions have been described up to now. Flavonoids have been related to antidepressant effects in cell lines and animal models by their action on the amine mechanisms protecting the neuroendocrine and immune systems. The current review includes an approach of some of the main results related to the action of flavonoids on depression found in the literature and a short view of the possible mechanisms involved. Thus, it highlights the potential emerging candidates with strong antidepressant effects which could be effective new compounds.
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