期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 116, 期 -, 页码 335-345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2018.04.047
关键词
Inonotus obliquus; Polysaccharides-chromium(III) complex; Anti-glycation; alpha-amylase and alpha-glucosidase inhibitory activity; Antioxidant activity
资金
- Natural Science Foundation of China [NSFC 31371879]
- National High Technology Research and Development Program (863 Program) of China [SS2013AA100207]
In the present study, the antioxidant activity, anti-glycation activity, alpha-amylase, alpha-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated. Their protective effects against H2O2-induced oxidative damages in hepatic L02 cells were also assessed. Results demonstrated that UIOPC and UIOPS exhibited remarkable DPPH scavenging activity, ferric reducing power and hemolysis inhibitory activity. UIOPC also showed significant inhibitory capacity on alpha-amylase and alpha-glucosidase than UIOPS (P < 0.05), suggesting a good regulation of the postprandial hyperglycemia. Three phases of advanced glycation end products (AGEs) formation were effectively inhibited by UIOPC and UIOPS. Moreover, pretreatment with UIOPC and UIOPS markedly attenuated the oxidative damage induced by H2O2 in hepatic L02 cells via enhancing the cell viability, inhibiting the morphology alteration and maintaining the integrity of mitochondria. These results indicated that the anti-diabetic mechanism of UIOPC might involve in the homoeostasis of blood glucose and the recovery of endogenous antioxidant system. The elucidation of the potential anti-diabetic mechanism will facilitate the further study and application of the polysaccharides-metal complex in the functional food industry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据