期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 118, 期 -, 页码 220-226出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2018.05.012
关键词
Pyrethroids; Cyfluthrin; Toxicokinetics; Blood and central nervous system
资金
- Comunidad de Madrid [S2013/ABI-2728]
- Ministerio de Economia, Industria y Competitividad. Spain [RTA2015-00010-C03-03]
Toxicokinetics of cyfluthrin after single oral [20 mg/kg body weight (bw)] and intravenous (IV) (3 mg/kg bw) doses were studied in rats. Serial blood samples were obtained after oral and IV administration. Brain tissue samples were also collected after oral administration. Cyfluthrin concentrations in plasma and brain tissues (hypothalamus, striatum, hippocampus and frontal cortex) were quantified using liquid chromatography tandem mass spectrometry (LC/MS). Cyfluthrin disposition was best described by the use of a two-compartment open model. When given orally, plasma kinetics showed an extensive oral absorption of cyfluthrin and a slow elimination. The area under the concentration-time curve [AUC((0-24h))] and maximal plasma concentration (Cmax) were 6.11 +/- 1.06 mg h/L and 0.385 +/- 0.051 mu g/mL, respectively; beta phase elimination half-life (T-1/2 beta) was (17.15 +/- 1.67 h). Oral bioavailability was found to be 71.60 +/- 12.36%. After oral administration, cyfluthrin was widely distributed to brain tissues. AUC((0-24h)), was significant higher in all tested brain tissues than in plasma. The largest discrepancy was found for hypothalamus. AUC((0-24h)), Cmax and T-1/2 beta in hypothalamus were 19.36 +/- 2.56 mg h/L, 1.21 +/- 0.11 mu g/g and 22.73 +/- 1.60 h, respectively. Assuming the identified toxicokinetics parameters, this study serves to better understand mammalian toxicity of pyrethroid cyfluthrin and to design further studies to characterize its neurotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据