期刊
FITOTERAPIA
卷 129, 期 -, 页码 102-107出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.06.016
关键词
Angelica sinensis; Apiaceae; Phthalide dimer; COX-2 inhibitory activity
资金
- National Natural Science Foundation of China [81773898, 81202916]
- Project for Youth Backbone Teachers in the University of Henan Province [2015GGJS-130]
- Science and Technology Project of Henan Province [152102310113]
Four new dimeric phthalides, angesinenolides C - F (1 - 4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of FIRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with IC50 values ranging from 29.32 +/- 0.07 to 137.91 +/- 0.24 mu M.
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