New compounds inhibiting lipid accumulation from the stems of Sabia parviflora

Four new compounds, sabianin A (1), sabianin B (2), sabianin C, (3) and sabianin D (4) together with seven known compounds (5-11) were isolated from the stems of Sabia parviflora. The structures of these compounds were elucidated by extensive spectroscopic analysis and by comparing their NMR data with those of related compounds. Their absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism spectra. The lipid-lowering effect of all the compounds was evaluated using a cell model of steatosis induced by oleic acid and palmitic acid. Compounds 3, 6, and 10 showed statistically significant lipid-lowering effect.