期刊
FITOTERAPIA
卷 128, 期 -, 页码 192-197出版社
ELSEVIER
DOI: 10.1016/j.fitote.2018.05.022
关键词
Vladimiria souliei; Sesquiterpene lactone dimers; Vlasouliolides J-K; Vlasoulioliones A-C; Neuroprotective
资金
- Chang Jiang Scholars Program
- National Nature Science Foundation of China [81473109, 81520108030, 21472238]
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [16DZ2280200]
- Scientific Foundation of Shanghai China [13401900103, 13401900101, 16401901600, 17401901700]
- National Major Project of China [2017ZX09301012-004]
- National Key Research and Development Program of China [2017YFC1700200]
- China Postdoctoral Science Foundation [2015M572740]
Two rare C-32 sesquiterpene lactone dimers, vlasouliolides J-K (1-2), together with three C-30 sesquiterpene dimers, vlasoulioliones A-C (3-5), were isolated from Vladimiria souliei. Their chemical structures were elucidated by NMR and MS spectroscopic data. Among them, compounds 1, 3 and 5 were unambiguously established by Cu-Ka X-ray crystallographic analysis. Furthermore, compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC50 value of 2.11 +/- 0.35 mu M. And the leakage of LDH from glutamate-induced PC-12 was significantly reduced by compound 1 at concentration of 10 mu M.
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