Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production

Three new diterpenoids, ebractenoids O similar to Q (1-3), and a new phenolic glucoside, gamma-pyrone-3-O-beta-D-(6-galloyl)glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)induced macrophages were evaluated. All of them exhibited significant inhibitory activity.