期刊
WORLD JOURNAL OF HEPATOLOGY
卷 7, 期 9, 页码 1282-1286出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4254/wjh.v7.i9.1282
关键词
Hepatitis B virus; Mutations; Hepatocellular carcinoma; Carcinogenesis; Chronic hepatitis B
资金
- Capital Science and Technology Development Foundation, Major Projects on Infectious Disease [2012ZX1002-008-05]
- High-Level Talent Academic Leader Training Program [2011-2-19]
- Capital Science and Tchnology Development Fund [2014-1-2181]
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). The HBV mutations, which include point mutation, deletion, insertion and truncation mutation of HBV gene in 4 open reading frames (S, C, P, X), are closely associated with HCC pathogenesis. Some mutations accumulated during chronic HBV infection could be regarded as a biomarker to predict the occurrence of HCC. The detection of the mutations in clinical practice could be helpful for defining better preventive and therapeutic strategies and, moreover, predicting the progression of liver disease.
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