期刊
FEBS LETTERS
卷 592, 期 12, 页码 1918-1928出版社
WILEY
DOI: 10.1002/1873-3468.13094
关键词
actin; kinesin; microtubule; minus end; organelle; plant
资金
- National Science Foundation [1616462, 1412063]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1616462] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1412063] Funding Source: National Science Foundation
In most eukaryotes, cytoplasmic dynein serves as the primary cytoskeletal motor for minus-end-directed processes along microtubules. However, land plants lack dynein, having instead a large number of kinesin-14s, which suggests that kinesin-14s may have evolved to fill the cellular niche left by dynein. In addition, land plants do not have centrosomes, but contain specialized microtubule-based structures called phragmoplasts that facilitate the formation of new cell walls following cell division. This Review aims to compile the evidence for functional diversification of kinesin-14s in land plants. Known functions include spindle morphogenesis, microtubule-based trafficking, nuclear migration, chloroplast distribution, and phragmoplast expansion. Plant kinesin-14s have also evolved direct roles in chromosome segregation in maize and novel biochemical features such as actin transport and processive motility in the homodimeric state.
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