期刊
FEBS LETTERS
卷 592, 期 17, 页码 2860-2873出版社
WILEY
DOI: 10.1002/1873-3468.13093
关键词
ADAR; adenosine to inosine; non-coding RNA; RNA editing
资金
- NIAID [PO1 AI099783-01, AI111139-01]
- NIDDK [DK104681-01]
- NIMH [R01 113407-01]
Adenosine to inosine (A-to-I) editing is the most abundant form of RNA modification in mammalian cells, which is catalyzed by adenosine deaminase acting on the double-stranded RNA (ADAR) protein family. A-to-I editing is currently known to be involved in the regulation of the immune system, RNA splicing, protein recoding, microRNA biogenesis, and formation of heterochromatin. Editing occurs within regions of double-stranded RNA, particularly within inverted Alu repeats, and is associated with many diseases including cancer, neurological disorders, and metabolic syndromes. However, the significance of RNA editing in a large portion of the transcriptome remains unknown. Here, we review the current knowledge about the prevalence and function of A-to-I editing by the ADAR protein family, focusing on its role in the regulation of gene expression. Furthermore, RNA editing-independent regulation of cellular processes by ADAR and the putative role(s) of this process in gene regulation will be discussed.
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