期刊
FEBS LETTERS
卷 592, 期 10, 页码 1693-1704出版社
WILEY
DOI: 10.1002/1873-3468.13077
关键词
DNA sensor; HTLV-1; IFI16; innate immune responses; reverse transcription intermediate
资金
- National Natural Science Foundation of China [U1504811, 31600697, U1704183]
- Key Scientific Research Projects in Universities of Henan Province [16A31003]
- Graduate Innovative Practice Base for clinical medicine of Xinxiang Medical University
Interferon (IFN)-inducible protein 16 (IFI16) regulates human immunodeficiency virus replication be inducing innate immune responses as a DNA sensor. Human T-Iymphotropic virus type 1 (HTLV-1), a delta retrovirus family member, has been linked to multiple diseases. Here, we report that IFI16 expression is induced by HTLV-1 infection or HTLV-1 reverse transcription intermediate (RTI) ssDNA90 transfection. IFI16 overexpression decreases HTLV-1 protein expression, whereas IFI16 knockdown increases it. Furthermore, the knockdown of W116 is followed by impaired innate immune responses upon HTLV-1 infection. In addition, IFI16 forms a complex with ssDNA90 and enhances ssDNA90-triggered innate immune responses. Collectively, our data suggest a critical role for IFI16 during HTLV-1 infection by interacting with HTLV-1 RTI ssDNA90 and restricting HTLV-1 replication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据