期刊
FEBS JOURNAL
卷 286, 期 2, 页码 399-412出版社
WILEY
DOI: 10.1111/febs.14522
关键词
achromatopsia; AMD; ER stress; glaucoma; neurodegernation; retinal degeneration; RGC; RPE; UPR; VEGF
资金
- NEI NIH HHS [R01 EY027335] Funding Source: Medline
- NINDS NIH HHS [R01 NS088485] Funding Source: Medline
- RRD VA [I01 RX002340] Funding Source: Medline
- BLRD VA [I01 BX002284] Funding Source: Medline
The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.
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