期刊
FEBS JOURNAL
卷 285, 期 12, 页码 2146-2160出版社
WILEY
DOI: 10.1111/febs.14446
关键词
bacterial infection; glycolysis; mitochondria; OXPHOS; Warburg-like metabolism
资金
- Institut Pasteur
- French Region Ile de France (DIM Malinf) [ANR-10-LABX-62-IBEID]
- Fondation pour la Recherche Medicale (FRM) [DEQ20120323697]
The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells. In this Review, we will summarize current knowledge on metabolic reprogramming and discuss putative causes underlying the preferential remodelling of host cells to Warburg-like metabolic programs during infection by intracellular bacteria.
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