期刊
FASEB JOURNAL
卷 32, 期 1, 页码 353-368出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201700543R
关键词
calcaneal tendon; proteoglycans; turnover; glycosaminoglycans; strength training
资金
- Sao Paulo Research Foundation (FAPESP) [2010/19390-5, 2011/11229-3, 2013/00798-2]
- Federal District Research Support Foundation (FAPDF) [193.000.653/2015]
- Brazilian National Council for Scientific and Technological Development (CNPq) [445069/2014-7]
In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period. Aging in sedentary rats showed down-regulation in key genes that regulated ECMremodeling. Moreover, the OS group showed a calcification focus in the distal region of the CT, with reduced blood vessel volume density. In contrast, resistance training was effective in up-regulating connective tissue growth factor, VEGF, and decorin gene expression in old rats. Resistance training also increased proteoglycan content in young and old rats in special small leucine-rich proteoglycans and blood vessels and prevented calcification in OT rats. These findings confirm that resistance training is a potentialmechanismin the prevention of aging-related loss in ECMand that it attenuates the detrimental effects of aging in tendons, such as ruptures and tendinopathies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据