期刊
JOURNAL OF APPLIED GERONTOLOGY
卷 34, 期 4, 页码 484-500出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0733464813512895
关键词
exercise; Alzheimer's disease; dementia; aging; cognition
类别
资金
- National Institute of Health [RR023247-04]
- American Health Assistance Foundation [A2009344]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000114]
Little is known about how aerobic exercise affects Alzheimer's disease (AD). The purpose of this pilot study was to test the impact of 6-month cycling on AD symptoms in community-dwelling older adults with mild-to-moderate AD, using a single-group, repeated-measures design (n = 26). AD symptoms were measured with the AD Assessment Scale-Cognitive (ADAS-Cog), Disability in AD (DAD), and Neuropsychiatric Inventory-Caregiver (NPI-Q) scales at baseline, 3 and 6 months. Data were analyzed using mixed linear models. The ADAS-Cog, DAD, and NPI-Q severity scores remained unchanged over the 6-month period, while caregiver distress decreased 40% (p < .05). We conclude that aerobic exercise may reduce AD symptoms and appears effective in decreasing caregiver distress. Further randomized controlled trials are needed to examine the effects of aerobic exercise in AD.
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