期刊
INFECTION AND CHEMOTHERAPY
卷 47, 期 2, 页码 81-97出版社
KOREAN SOC ANTIMICROBIAL THERAPY
DOI: 10.3947/ic.2015.47.2.81
关键词
Metallo-beta-lactamase; Pseudomonas aeruginosa; Carbapenem; Epidemiology; Multidrug resistance
资金
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A120843]
- Korea Health Promotion Institute [HI12C0756090015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Metallo-beta-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all beta-lactam antibiotics except monobactams. There are various types of metallo-beta-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-beta-lactamase (VIM), Sao Paulo metallo-beta-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-beta-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
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