期刊
FUNGAL GENETICS AND BIOLOGY
卷 78, 期 -, 页码 16-48出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2015.02.009
关键词
Cryptic species; Cryptococcus gattii; Cryptococcus neoformans; Yeast; Pathogen; Taxonomy
资金
- Odo van Vloten Foundation
- Naresuan University, Thailand
Phylogenetic analysis of II genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C neoformans var. grubii and C neoformans var. neoformans as separate species, and five species within C gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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