期刊
EXTREME MECHANICS LETTERS
卷 3, 期 -, 页码 45-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eml.2015.02.005
关键词
Stretchable electronics; Balloon catheters; Ablation; Angioplasty; Hemodynamics; Mechanics
资金
- National Institutes of Health [R01EB019337]
Balloon catheter-based techniques that apply mechanical force to blood vessel walls have dramatically advanced the standard of care for patients with vascular disease. But balloons are limited in their therapeutic potential because they rely on mechanics alone and lack electronically active materials. Recent advances in balloon catheters with integrated electrodes have offered additional treatment capabilities through the application of both mechanical contact force and radio frequency electromotive force. However, these smart balloons remain limited in their mechanics and their ability to provide diagnostic information about local vessel hemodynamics and tissue health near treatment zones. Here, we demonstrate a novel instrumented balloon catheter system that contains stretchable electrodes and thermal-based blood flow sensors, providing hemodynamic information, electrical stimulation, and ablation therapy on a single device. This system accommodates high inflation pressure (similar to 2 atm) and twisting and bending over a broad range of vascular diameters and geometries. Finite element and analytical modeling capture the anisotropic mechanical and thermal properties of the device during cycles of inflation and deflation in a simulated biological environment. Bench-top ablation and in vivo blood flow measurements highlight the utility of this technology for clinical application. (C) 2015 Elsevier Ltd. All rights reserved.
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