期刊
EXPERT REVIEW OF PROTEOMICS
卷 15, 期 5, 页码 371-390出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14789450.2018.1468754
关键词
Leishmaniasis; virulence; vaccine; bioinformatics; proteomics
资金
- NIAID, NIH [2U19 AI074321]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P50AI074321, U19AI074321] Funding Source: NIH RePORTER
Introduction: Leishmania spp. are causative agents of leishmaniasis, a broad-spectrum neglected vector-borne disease. Genomic and transcriptional studies are not capable of solving intricate biological mysteries, leading to the emergence of proteomics, which can provide insights into the field of parasite biology and its interactions with the host.Areas covered: The combination of genomics and informatics with high throughput proteomics may improve our understanding of parasite biology and pathogenesis. This review analyses the roles of diverse proteomic technologies that facilitate our understanding of global protein profiles and definition of parasite development, survival, virulence and drug resistance mechanisms for disease intervention. Additionally, recent innovations in proteomics have provided insights concerning the drawbacks associated with conventional chemotherapeutic approaches and Leishmania biology, host-parasite interactions and the development of new therapeutic approaches.Expert commentary: With progressive breakthroughs in the foreseeable future, proteome profiles could provide target molecules for vaccine development and therapeutic intervention. Furthermore, proteomics, in combination with genomics and informatics, could facilitate the elimination of several diseases. Taken together, this review provides an outlook on developments in Leishmania proteomics and their clinical implications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据