期刊
COMPUTATION
卷 3, 期 2, 页码 177-196出版社
MDPI
DOI: 10.3390/computation3020177
关键词
mammal phylogeny; phylogeny reconstruction; molecular phylogenetics; heterogeneous modeling; placental mammals
资金
- Dublin City University under the Daniel O'Hare Research scholarship
- Irish research Council Government of Ireland Scholarship [GOIPG/2014/306]
- Fulbright commission for their Fulbright Scholar Award
- Science Foundation Ireland for Research Frontiers Program [EOB2673]
- DJEI/DES/SFI/HEA
There are numerous phylogenetic reconstruction methods and models availablebut which should you use and why? Important considerations in phylogenetic analyses include data quality, structure, signal, alignment length and sampling. If poorly modelled, variation in rates of change across proteins and across lineages can lead to incorrect phylogeny reconstruction which can then lead to downstream misinterpretation of the underlying data. The risk of choosing and applying an inappropriate model can be reduced with some critical yet straightforward steps outlined in this paper. We use the question of the position of the root of placental mammals as our working example to illustrate the topological impact of model misspecification. Using this case study we focus on using models in a Bayesian framework and we outline the steps involved in identifying and assessing better fitting models for specific datasets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据