期刊
NATURE REVIEWS CANCER
卷 15, 期 6, 页码 334-346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3929
关键词
-
类别
资金
- US National Institutes of Health [GM082856, EY022299]
- Leukemia and Lymphoma Society (LLS)
- American Cancer Society (ACS)
- Stand Up to Cancer
- Research to Prevent Blindness
- Knights Templar Eye Foundation
Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. Although the human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member KMT2A in this disease, recent exome-sequencing studies revealed KMT2 genes to be among the most frequently mutated genes in many types of human cancers. Efforts to integrate the molecular mechanisms of KMT2 with its roles in tumorigenesis have led to the development of first-generation inhibitors of KMT2 function, which could become novel cancer therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据