期刊
EXPERIMENTAL DERMATOLOGY
卷 27, 期 8, 页码 841-846出版社
WILEY
DOI: 10.1111/exd.13674
关键词
corneodesmosome; cornified cell envelope; keratohyalin granules; lamellar granules; tight junctions
类别
资金
- Japan Science and Technology Agency [17K10203]
- Grants-in-Aid for Scientific Research [17K10203] Funding Source: KAKEN
The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesmosomes, tight junctions, cornified cell envelope and keratin filaments. In this review, we discuss the current knowledge of their ultrastructure, their molecular basis and their relevance to skin disease.
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