期刊
RSC ADVANCES
卷 5, 期 52, 页码 41803-41813出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra00925a
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资金
- Department of Science and Technology, New Delhi [SR/FT/CS-40/2010]
A novel series of 2-allyl-6-substituted-benzo[de]isoquinoline-1,3-diones has been synthesized and evaluated against 60 human tumor cell lines for their in vitro antitumor activities. Compound 6b proved to be the most active member at a single dose concentration of 10 mu M and broad spectrum of antitumor activity with GI(50), TGI and LC50 values of 84.2 nM, 27.6 mu M and 89.3 mu M respectively at five dose concentration levels. The DNA binding properties of this compound has been investigated by a UV-Vis and fluorescence spectrophotometer as well as thermal denaturation experiments. Molecular docking studies of compound 6b have also supported the corresponding biological data.
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