Third generation dual-source CT enables accurate diagnosis of coronary restenosis in all size stents with low radiation dose and preserved image quality

To investigate the diagnostic performance of low dose stent imaging in patients with large (3 mm) and small (< 3 mm) calibre stents by third-generation dual-source CT. Symptomatic patients suspected of having in-stent restenosis (ISR) were prospectively enrolled. Coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) were performed within 1 month for correlation. Binary ISR was defined as an in-stent neointimal proliferation with diameter stenosis 50%. The radiation dose and image quality of CCTA were also assessed. Sixty-nine patients with 140 stents were ultimately included for analysis. The mean total radiation dose of CCTA was 1.3 +/- 0.72 mSv in all patients and 0.95 +/- 0.17 mSv in patients with high pitch acquisition. The overall diagnostic accuracy of CCTA stent imaging of patient-based, lesion-based and stent-based analysis was 95.7%, 94.1% and 94.3%, respectively. Further, the diagnostic accuracy of CCTA in the small calibre stent group (diameter < 3 mm) was slightly lower than that of the large calibre stent group (diameter 3 mm) (88.5% versus 98.7%, p = 0.01). Third-generation dual-source CT enables accurate diagnosis of coronary ISR of both large and small calibre stents. Low radiation dose could be achieved with preserved image quality. aEuro cent Third-generation DSCT enables accurate diagnosis of coronary ISR of all size stents. aEuro cent Low radiation dose could be achieved with preserved image quality. aEuro cent The diagnostic accuracy of CCTA of small calibre stents was 88.5%.