期刊
EUROPEAN POLYMER JOURNAL
卷 105, 期 -, 页码 17-25出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2018.05.023
关键词
Carboxymethyl beta-cyclodextrin; Carboxymethyl cellulose; Hydrogel; Complexation; Swelling ability; Tetracycline
资金
- Konkuk University Researcher Fund in 2017
- Bio & Medical Technology Development Program of the NRF - Korean Government, MSIP [NRF-2015M3A9B8031831]
Carboxymethyl cellulose (CMC)-based hydrogels have superabsorbent properties but low mechanical strength. Variation of other hydrogel components might improve the mechanical strength, but has been occasionally seen to decrease the swelling and drug-loading capacity. To address these problems, we designed a dual-component system, consisting of both carboxymethyl beta-cyclodextrin (cm beta CD) and CMC. We synthesized the hydrogels by crosslinking beta CD or cm beta CD with both cellulose (CEL) and CMC to evaluate their intrinsic mechanical strength and swelling capacity. The characteristic structure and morphology of each hydrogel was determined by Fourier transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy, and field emission scanning electron microscopy. The storage modulus of the cm beta CD/CMC gel was nearly eight-fold higher than that of the CMC gel only in rheology tests; the compressive strength was also enhanced while still retaining high swelling ability. We also investigated the drug-loading capacity and subsequent release properties, using tetracycline as a drug model. The cm beta CD/CMC hydrogels showed the most effective tetracycline-loading capacity with the highest antibacterial activity among all hydrogels. They also showed the highest mechanical strength and the best drug release properties apart from the appreciable swelling capacity. Furthermore, cm beta CD/CMC hydrogels are non-cytotoxic towards human dermal fibroblasts, suggesting their safe use as nontoxic, bio-friendly, and effective drug delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据