期刊
WORLD JOURNAL OF PSYCHIATRY
卷 5, 期 2, 页码 193-209出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.5498/wjp.v5.i2.193
关键词
Auditory verbal hallucinations; Perception; Executive functions; Brain imaging; Glutamate; Gamma-amino-butyric-acid; Schizophrenia
类别
资金
- European Research Council Advanced Grant [249516]
- Research Council of Norway FRIBIOMED Grant [807696]
- SFF Grant [222373]
- European Research Council (ERC) [249516] Funding Source: European Research Council (ERC)
In this invited review I provide a selective overview of recent research on brain mechanisms and cognitive processes involved in auditory hallucinations. The review is focused on research carried out in the VOICE ERC Advanced Grant Project, funded by the European Research Council, but I also review and discuss the literature in general. Auditory hallucinations are suggested to be perceptual phenomena, with a neuronal origin in the speech perception areas in the temporal lobe. The phenomenology of auditory hallucinations is conceptualized along three domains, or dimensions; a perceptual dimension, experienced as someone speaking to the patient; a cognitive dimension, experienced as an inability to inhibit, or ignore the voices, and an emotional dimension, experienced as the voices having primarily a negative, or sinister, emotional tone. I will review cognitive, imaging, and neurochemistry data related to these dimensions, primarily the first two. The reviewed data are summarized in a model that sees auditory hallucinations as initiated from temporal lobe neuronal hyper-activation that draws attentional focus inward, and which is not inhibited due to frontal lobe hypo-activation. It is further suggested that this is maintained through abnormal glutamate and possibly gamma-amino-butyric-acid transmitter mediation, which could point towards new pathways for pharmacological treatment. A final section discusses new methods of acquiring quantitative data on the phenomenology and subjective experience of auditory hallucination that goes beyond standard interview questionnaires, by suggesting an iPhone/iPod app.
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