New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions

Purine bases have attracted much attention due to their potential biological activities. Developing more efficient methods for the modification of purine bases with a substitution such as aryl or alkyl is particularly interesting. This review gives an overview of new developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions in recent years.