期刊
CURRENT ALZHEIMER RESEARCH
卷 12, 期 5, 页码 434-438出版社
BENTHAM SCIENCE PUBL LTD
关键词
2-acetylbenzo[b]thiophen-3-olate; Alzheimer's disease; beta-amyloid; ruthenium(II); tris(2-pyridylmethyl)amine
资金
- Hong Kong Polytechnic University (Internal Competitive Research Grant for Newly Recruited Staff)
- National Science Foundation of China [21401157]
- Shenzhen Municipal Science and Technology Industry and Information Technology Commission Research Grant [JCYJ20140819153305700]
- Hong Kong Baptist University [FRG2/13-14/008, FRG2/14-15/004]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
- Health and Medical Research Fund [HMRF/13121482, HMRF/14130522]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- State Key Laboratory of Environmental and Biological Analysis Research Grant [SKLP-14-15-P001]
- State Key Laboratory of Synthetic Chemistry
- Science and Technology Development Fund
- Macao SAR [103/2012/A3]
- University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS]
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of beta-amyloid fibrillo-genesis. [Ru(tpa)(bt)]ClO4 1 (bt = 2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of A beta(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
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