期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 46, 期 1, 页码 93-107出版社
IOS PRESS
DOI: 10.3233/JAD-143054
关键词
Alzheimer's disease; amnestic mild cognitive impairment; cell cytotoxicity; chemotaxis; natural killer cells; phenotyping; toll-like receptors
资金
- Canadian Institutes of Health Research (CIHR) [106634]
- Universite de Sherbrooke
- Research Center on Aging
Alzheimer's disease (AD) is a progressive irreversible neurological brain disorder characterized by accumulation of amyloid-beta, amyloid plaques, and neurofibrillary tangles. Inflammation and immune alterations have been linked to AD, suggesting that the peripheral immune system plays a role during the asymptomatic period of AD. NK cells participate in innate immune surveillance against intracellular pathogens and malignancy but their role in AD remains controversial. We have investigated changes in peripheral NK cell phenotypes and functions in amnestic mild cognitive impairment (aMCI, n = 10), patients with mild AD (mAD, n = 11), and healthy elderly controls (n = 10). Patients selected according to NINCDS-ADRDA criteria were classified using neuropsychological assessment tests. Phenotype analysis revealed differences in expression of CD16 (increased in mAD), NKG2A (decreased in aMCI), and TLR2 and TLR9 (both decreased in mAD). Functional assays revealed that NK cell killing activity and degranulation (CD107 expression) were unchanged in the three groups. In contrast, expression of the CD95 receptor was increased in aMCI and mAD. Granzyme B expression and cytokine production (TNF alpha, IFN gamma) were increased in aMCI but not in mAD. CCL19-but not CCL21-dependent chemotaxis was decreased in aMCI and mAD, despite the fact that CCR7 expression was increased in aMCI. Our data suggest that the number of alterations observed in peripheral NK cells in aMCI represent an activation state compared to mAD patients and that may reflect an active immune response against a still to be defined aggression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据