期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 833, 期 -, 页码 1-7出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2018.05.020
关键词
alpha-Tocopherol; Depression; Autophagy; mTOR; AMPK; Behaviour
资金
- Chinese National Natural Science Foundation [81073002, 81673625]
- Program of Collaborative Innovation Center of Chinese Medicinal Material Resources Industrialization of Jiangsu Province [ZDXM-3-16]
- National Twentieth Five-Year Technology [2011BAI04B06]
The purpose of the present study was to investigate whether alpha-tocopherol exhibited neuro-protective effects in chronic unpredictable mild stress (CUMS) mice through the regulation of autophagy. Deficits in behavioural tests, including a sucrose preference test, open field test, forced swim test, and tail suspension test, were ameliorated following alpha-tocopherol administration. To study the potential mechanism, western blots were performed on both prefrontal cortex and hippocampus samples. Similar to the degree of autophagy, the activities of adenosine monophosphate-activated protein kinase (AMPK) and Unci-51 like autophagy activating kinase-1 (ULK1) were decreased after CUMS stimulation. In addition, we also found increased activity of the mammalian target of rapamycin (mTOR), which was significantly affected following administration of a-tocopherol, as well as its three downstream pathways. Taken together, our study found that alpha-tocopherol might potentially promote autophagy to induce anti-depressive responses in CUMS mice though the AMPK/mTOR pathway.
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