期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 829, 期 -, 页码 38-43出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2018.03.045
关键词
NLRC5; Renal fibrosis; Transforming growth factor beta 1 (TGF-beta 1); Extracellular matrix (ECM)
资金
- Scientific and Technological Project of Henan Province in China [201003089]
NLRC5, the largest member of the Nucleotide-binding domain and leucine-rich repeat (NLR) protein family, is recently proven to be a critical modulator in fibrogenesis. However, the role of NLRC5 in renal fibrosis remains unknown. In the present study, we investigated the effects of NLRC5 on transforming growth factor beta 1 (TGF-beta 1)stimulated rat renal fibroblasts in vitro. Our results showed that the expression of NLRC5 was also obviously upregulated in renal fibrosis tissues and TGF-beta 1-treated NRK-49F cells. Knockdown of NLRC5 inhibited the proliferation of NRK-49F cells induced by TGF-beta 1, as well as suppressed the accumulation of extracellular matrix (ECM) in NRK-49F cells induced by TGF-beta 1. Furthermore, knockdown of NLRC5 inhibited the expression of phosphorylated Smad3 in TGF-beta 1-treated NRK-49F cells. In conclusion, our results show that knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF-beta 1/Smad signaling pathway. Therefore, NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis.
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