期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 130, 期 -, 页码 200-206出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2018.06.029
关键词
Mucus; Mucus-penetrating particles; Nanotechnology; Poly(lactic-co-glycolic acid); Rectal administration
资金
- Programa Gilead GENESE, Gilead Portugal [PGG/002/2016]
- Norte Portugal Regional Operational Programme (NORTE 2020), through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000012]
- FEDER Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
- Portuguese funds through FCT Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior [POCI-01-0145-FEDER-007274]
- FCT [SFRH/BD/96519/2013, SFRH/BPD/92934/2013]
- i3S Scientific Platform: Biointerfaces and Nanotechnology (BN)
- i3S Scientific Platform: b.IMAGE - Bioimaging Centre for Biomaterials and Regenerative Therapies
- i3S Scientific Platform: Animal Facility
Dense surface modification with short chain polyethylene glycol (PEG) has been previously demonstrated as favoring the transport of nanoparticles (NPs) across mucus. However, the ability of such approach to influence the distribution and retention of NPs along the length of the colorectum after rectal delivery has not been previously established. Herein, the distribution and retention of poly(lactic-co-glycolic acid) NPs modified with PEG in a non-covalent fashion are reckoned in a mouse model. Despite overall rapid depletion, both PEG modified and non-modified NPs are able to reach the middle segment of the colon. PEG-modified NPs are able to enhance retention up to at least two hours post-administration, contrasting with nearly residual levels observed for non-modified NPs after 15 min. The ability of PEG-modified NPs to putatively cross mucus also appears to promote association with tissues. Overall, the work provides significant insights as to the behavior of NPs in the colorectum, which could be valuable for the development of rectal nanomedicines. It further reinforces the potential usefulness of PEG-modified NPs as mucus-penetrating carriers for mucosal drug delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据