期刊
EUROPEAN JOURNAL OF PEDIATRICS
卷 177, 期 5, 页码 699-707出版社
SPRINGER
DOI: 10.1007/s00431-018-3107-0
关键词
Asthma; Atherosclerosis; Epidemiology; Carotid intima media thickness
类别
资金
- Swiss National Science Foundation [PMPDP3_129021/1, PMPDP3_141671/1, 33CSCO-134276/1, 33CSCO-108796, 3247BO104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200042532, 4026-028099]
- canton's Lung League of Basel Stadt/Basel Landschaft and Graubunden
- Stiftung ehemals Bundner Heilstatten
- Swiss National Science Foundation (SNF) [PMPDP3_141671, PMPDP3_129021] Funding Source: Swiss National Science Foundation (SNF)
Respiratory diseases are associated with increased cardiovascular risk in adults, but little is known on the early impact on the vasculature in youth. The SAPALDIA Youth study, the offspring study of the Swiss Study on Air Pollution and Lung and Heart Disease In Adults (SAPALDIA), investigated the association between physician-diagnosed asthma status and common carotid artery intima media thickness (CIMT). Offspring underwent standardized clinical protocols and provided information on early life factors, health, and lifestyle. The association between per subject averages of CIMT and asthma was estimated using mixed linear regression analyses adjusting for main confounders, testing for interaction with gender and age. Of 257 offspring (mean age 15 years, 53% female), 11.5% reported doctor-diagnosed asthma (male 17%, female 7%). Mean CIMT was significantly different by gender (male 0.53 mm (+/- 0.045), female 0.50 mm (+/- 0.048); p < 0.001). Interaction was highly significant by gender (p = 0.001) with significantly increased CIMT in asthmatic vs. non-asthmatics boys (difference 0.023 mm, 95% CI 0.003; 0.043), as compared to girls. Conclusion: Our study suggests an increased risk for early vascular change in adolescent asthmatic boys. Whereas the small number of girls limits the interpretation, the result necessitates further research into sex-specific atherosclerotic burden related to respiratory health in adolescence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据