期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 24, 页码 3193-3201出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800196
关键词
Synthetic methods; Earth-abundant metals; Cobalt; Cycloaddition; Catalyst activation; Microwave; Pyridines
The robust Co-I precatalyst [CpCo(P{OEt}(3))(trans-MeO2CHC=CHCO2Me)] was investigated in cyclotrimerizations, furnishing benzenes and pyridines from triynes, diynes and nitriles, comparing the influence of different ways of energy supply; namely, irradiation and conventional (thermal) or microwave heating. The precatalyst was found to work under all conditions, including the possibility to catalyze cyclotrimerizations at room temperature under photochemical conditions at longer reaction times. Performance of the reactions in a microwave reactor proved to be the most time-efficient way to rapidly assemble the expected reaction products; however, careful selection of reaction conditions can be required. The synthesis of pyridines and isoquinolines successfully involved the utilization of versatile functionalized nitriles, affording structurally interesting reaction products. Comparison with the known and often applied precatalyst CpCo(CO)(2) demonstrated the significantly higher reactivity of the CpCoI-phosphite-olefin precatalyst.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据