期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 6, 页码 723-729出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701476
关键词
Synthetic methods; 1,2,3-Triazole; C-H activation; Rhodium; Heterogeneous catalysis
资金
- National Natural Science Foundation of China [81573286, 81773577, 81602954, 21472130]
A rhodium-catalyzed ortho-cyanation protocol for 2-aryl-1,2,3-triazole has been developed by using N-cyano-N-phenyl-p-toluensulfonamide (NCTS) as an environmentally friendly cyanide source. This simple cyanation reaction provides a new protocol for the diversification of benzonitriles in moderate to good yields and tolerates useful functional groups. In addition, the method was used to synthesize 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, which is the key intermediate of suvorexant.
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