期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 1, 页码 48-59出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701335
关键词
Natural products; Fungi; Terpenoids; Biological activity; Structure elucidation
资金
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National High Technology Research and Development Program of China (863 Project) [2013AA092902]
- National Natural Science Fund of China [41476121, 81402844, 81502936, 31600014]
- Beijing Medical Award Foundation [YJHYXKYJJ-125]
- Fund of the Science and Technology Commission of Shanghai Municipality [15431900900]
Two rare 6(D)/5(E) ring-fused meroterpenoids, eupeniacetal A (1) and eupeniacetal B (2), and three new meroterpenoids, 1-methoxy-hydropreaustinoid A1 (3), hydroberkeleyone B (4), and 22-deoxy-10-oxominiolutelide B (5), as well as five known meroterpenoids, 22-deoxyminiolutelide B (6), preaustinoid A1 (7), berkeleyone C (8), berkeleyacetal A (9), and preaustinoid A3 (10), have been isolated, through the aid of LC-MS, from the sponge-derived fungus Eupenicillium sp. 6A-9. The structures of these meroterpenoids were elucidated by detailed spectroscopic analysis, comparison with literature data, and single-crystal X-ray diffraction. The absolute configurations were assigned by means of TDDFT/ECD and [](D) calculations as well as by X-ray diffraction analysis. These compounds showed inhibitory activity towards TNF- production in the induced THP-1 cell line but were inactive against normal tumor cell lines.
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