期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 12, 页码 1437-1442出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701807
关键词
Nitrogen heterocycles; Hypervalent compounds; Iodine; Indoles; Oxidation
资金
- National Natural Science Foundation of China [21506191, 21676252]
A practical conversion of indoles into the corresponding 2-oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2-oxindoles in up to 90% yield. Furthermore, Ropinirole, a drug used to alleviate the symptoms of Parkinson's disease, was synthesized in three steps in an overall yield of 44% using this method.
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