期刊
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
卷 1, 期 4, 页码 433-+出版社
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2015.04.005
关键词
Adaptive Immunity; Dextran Sulfate Sodium; Experimental Colitis; Immune Response; Innate Immunity; GMCSF; Monocyte; T Cell
资金
- Broad Medical Research Program of the Eli and Edythe Broad Foundation [BMRP IBD0201]
- German Research Foundation [DFG DA1161/4-1, DA1161/4-1, DFG SU195/3-2, DFG SF1009B08]
- Innovative Medical Research Program of the University of Munster (IMF) [DA120904, DA3U21003]
- German Research Foundation (DFG) [DA1161/5-1]
Monocytes can mediate the clinical response of granulocyte macrophage colony-stimulating factor (GM-CSF) in colitis. GM-CSF-activated monocytes express adenosine triphosphate-converting enzymes (CD39/CD73) to generate adenosine which possibly induces regulatory T cells. This mechanism of monocytes may control intestinal inflammation.
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