4.5 Article

Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial

期刊

EUROPEAN JOURNAL OF NUTRITION
卷 58, 期 5, 页码 2019-2028

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s00394-018-1760-8

关键词

Vitamin D supplementation; PCOS; RCT; Insulin resistance; Glucose sensitivity

资金

  1. Medical University of Graz
  2. Austrian Science Fund (FWF) [KLI 274]

向作者/读者索取更多资源

Purpose Vitamin D status may be associated with insulin resistance and other key features of polycystic ovary syndrome (PCOS), but data from preliminary randomized controlled trials (RCTs) are conflicting. Therefore, we aimed to investigate the effects of vitamin D supplementation on plasma glucose area under the curve (AUCgluc, primary outcome measure) and on other metabolic and endocrine parameters (secondary outcome measures). Methods This study was a single-center, double-blind, randomized placebo-controlled trial conducted between December 2011 and July 2017 at the Medical University of Graz, Austria. One-hundred and eighty women with PCOS and 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L were randomized in a 2:1 ratio to either receive 20,000IU of cholecalciferol weekly or placebo over 24 weeks. Primary outcome was the between-group difference in AUCgluc at study end while adjusting for baseline values. Results In total, 123 participants completed the study [age 25.9+/-4.7 years; BMI 27.5 +/- 7.3 kg/m(2); baseline 25(OH)D 48.8 +/- 16.9 nmol/L, baseline fasting glucose 84 +/- 8 mg/dL]. Vitamin D supplementation lead to a significant increase in 25(OH)D [mean treatment effect 33.4 nmol/L; 95% confidence interval (CI) 24.5 to 42.2; p<0.001] but had no significant effect on AUCgluc (mean treatment effect -9.19; 95% CI -21.40 to 3.02; p=0.139). Regarding secondary outcome measures, we observed a significant decrease in plasma glucose at 60 min during oral glucose tolerance test (mean treatment effect -10.2 mg/dL; 95% CI -20.2 to -0.3; p=0.045). Conclusions Vitamin D supplementation had no significant effect on metabolic and endocrine parameters in PCOS with the exception of a reduced plasma glucose during OGTT.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据