期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 48, 期 1, 页码 1620-1634出版社
WILEY
DOI: 10.1111/ejn.13971
关键词
brain; fluoxetine; oxidative phosphorylation; UCP 2
资金
- Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco [APQ 1026.4-09/12, APQ-0164-4.05/15]
The serotonin reuptake is mainly regulated by the serotonin transporters (SERTs), which are abundantly found in the raphe nuclei, located in the brainstem. Previous studies have shown that dysfunction in the SERT has been associated with several disorders, including depression and cardiovascular diseases. In this manuscript, we aimed to investigate how gender and the treatment with a serotonin selective reuptake inhibitor (SSRI) could affect mitochondrial bioenergetics and oxidative stress in the brainstem of male and female rats. Fluoxetine, our chosen SSRI, was used during the neonatal period (i.e., from postnatal Day 1 to postnatal Day 21PND1 to PND21) in both male and female animals. Thereafter, experiments were conducted in adult rats (60days old). Our results demonstrate that, during lactation, fluoxetine treatment modulates the mitochondrial bioenergetics in a sex-dependent manner, such as improving male mitochondrial function and female antioxidant capacity.
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