期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 150, 期 -, 页码 864-875出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.03.042
关键词
Coumarin-oxime ether; Anti-tubercular; DNA cleavage; Cytotoxicity; BSA interaction
资金
- SERB
- Department of Science and Technology [CS/097/2013, SB/FT/CS-100/2013, YSS/2015/001893]
- Centre for Nano and Material Sciences, Jain University, Bangalore,India
As a contribution to the development of novel coumarin-oxime ether conjugates with therapeutically interesting properties, a series of coumarin-oxime ether (1a-1j) was synthesised using S(N)2 reaction of bromomethyl coumarins with butane-2,3-dione monoxime. Invitro anti-tuberculosis activityagainstMTBH(37)Rv strain was established for the coumarin-oxime ether (1a-1j). Most of the compounds exhibited significant activity with minimum inhibitory concentration (MIC)in the range of 0.04-3.12 mu g mL(-1). Compound (1h) was identified as a hit candidate exhibiting MIC of 0.04 mu g mL(-1), closer to the MIC value of Isoniazid (0.02 mu g mL(-1)), a commercially available drug for the treatment of tuberculosis. Compound 1h also displayed a low level of toxicity in Vero cells along with a good safety profile in vitro. Compounds that showed potent anti-tubercular activity were also found to cleave DNA more efficiently and thereby exhibit nuclease activity. The most active compound (1h) was further studied to deduce the mode of interaction with model serum protein, bovine serum albumin (BSA). (C) 2018 Elsevier Masson SAS. All rights reserved.
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