期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 153, 期 -, 页码 2-28出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2017.12.059
关键词
Anti-inflammatory; Anti-rheumatism; mPGES-1; Enzyme inhibitors; Plant-derived compounds
资金
- Austrian Science Fund (FWF) project [P25971-B23]
- Polish KNOW (Leading National Research Centre) Scientific Consortium Healthy Animal-Safe Food of Ministry of Science and Higher Education [05-1/KNOW2/2015]
Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged tissue. It is a complex process, which involves the release of diverse regulatory mediators. The current anti-inflammatory agents are challenged by multiple side effects and thus, new effective therapies are highly needed. The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal approach in the management of inflammatory disorders, but need further clinical trials in order to be ultimately validated. (C) 2017 Elsevier Masson SAS. All rights reserved.
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